Mist after cleansing when skin feels warm, tight, or reactive, gently press away excess, and follow promptly with serum or cream. This is the soothing mist in the group and the one I would choose for drier mature skin or a barrier made touchy by travel and treatment.
It is optional comfort, not a moisturizer by itself. Sealing it in matters more than repeatedly spraying water and letting it evaporate.