Massage over wet acne-prone skin for about 60 seconds, then rinse thoroughly. Start every other morning for the first two weeks; 4% benzoyl peroxide is plenty for a leave-on retinoid routine, and the goal is clearer skin rather than the driest face in America.
Benzoyl peroxide can bleach towels, pillowcases, and hairlines, so rinse well and use white linens. If you are mostly dealing with blackheads or the wash feels drying, use Vanicream Gentle Facial Cleanser in the morning and let Differin do the heavy lifting at night.